5-HT1E receptor (5ht1e_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT1E receptor
GENE
HTR1E
ORGANISM
Human (Homo sapiens)
ALT. NAMES
5-hydroxytryptamine receptor 1E, 5-HT-1E, 5-HT1E, S31, Serotonin receptor 1E
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
I
|
T
|
N
|
C
|
T
|
T
|
E
|
A
|
10 |
TM1 | |||||||||
S
|
M
|
A
|
I
|
R
|
P
|
K
|
T
|
I
|
T
|
20 |
E
|
K
|
M
|
L
|
I
|
C
|
M
|
T
|
L
|
V
|
30 |
V
|
I
|
T
|
T
|
L
|
T
|
T
|
L
|
L
|
N
|
40 |
L
|
A
|
V
|
I
|
M
|
A
|
I
|
G
|
T
|
T
|
50 |
ICL1 | TM2 | ||||||||
K
|
K
|
L
|
H
|
Q
|
P
|
A
|
N
|
Y
|
L
|
60 |
I
|
C
|
S
|
L
|
A
|
V
|
T
|
D
|
L
|
L
|
70 |
V
|
A
|
V
|
L
|
V
|
M
|
P
|
L
|
S
|
I
|
80 |
ECL1 | |||||||||
I
|
Y
|
I
|
V
|
M
|
D
|
R
|
W
|
K
|
L
|
90 |
TM3 | |||||||||
G
|
Y
|
F
|
L
|
C
|
E
|
V
|
W
|
L
|
S
|
100 |
V
|
D
|
M
|
T
|
C
|
C
|
T
|
C
|
S
|
I
|
110 |
L
|
H
|
L
|
C
|
V
|
I
|
A
|
L
|
D
|
R
|
120 |
ICL2 | |||||||||
Y
|
W
|
A
|
I
|
T
|
N
|
A
|
I
|
E
|
Y
|
130 |
TM4 | |||||||||
A
|
R
|
K
|
R
|
T
|
A
|
K
|
R
|
A
|
A
|
140 |
L
|
M
|
I
|
L
|
T
|
V
|
W
|
T
|
I
|
S
|
150 |
I
|
F
|
I
|
S
|
M
|
P
|
P
|
L
|
F
|
W
|
160 |
ECL2 | |||||||||
R
|
S
|
H
|
R
|
R
|
L
|
S
|
P
|
P
|
P
|
170 |
S
|
Q
|
C
|
T
|
I
|
Q
|
H
|
D
|
H
|
V
|
180 |
TM5 | |||||||||
I
|
Y
|
T
|
I
|
Y
|
S
|
T
|
L
|
G
|
A
|
190 |
F
|
Y
|
I
|
P
|
L
|
T
|
L
|
I
|
L
|
I
|
200 |
L
|
Y
|
Y
|
R
|
I
|
Y
|
H
|
A
|
A
|
K
|
210 |
S
|
L
|
Y
|
Q
|
K
|
R
|
G
|
S
|
S
|
R
|
220 |
ICL3 | |||||||||
H
|
L
|
S
|
N
|
R
|
S
|
T
|
D
|
S
|
Q
|
230 |
N
|
S
|
F
|
A
|
S
|
C
|
K
|
L
|
T
|
Q
|
240 |
T
|
F
|
C
|
V
|
S
|
D
|
F
|
S
|
T
|
S
|
250 |
D
|
P
|
T
|
T
|
E
|
F
|
E
|
K
|
F
|
H
|
260 |
A
|
S
|
I
|
R
|
I
|
P
|
P
|
F
|
D
|
N
|
270 |
D
|
L
|
D
|
H
|
P
|
G
|
E
|
R
|
Q
|
Q
|
280 |
TM6 | |||||||||
I
|
S
|
S
|
T
|
R
|
E
|
R
|
K
|
A
|
A
|
290 |
R
|
I
|
L
|
G
|
L
|
I
|
L
|
G
|
A
|
F
|
300 |
I
|
L
|
S
|
W
|
L
|
P
|
F
|
F
|
I
|
K
|
310 |
E
|
L
|
I
|
V
|
G
|
L
|
S
|
I
|
Y
|
T
|
320 |
ECL3 | TM7 | ||||||||
V
|
S
|
S
|
E
|
V
|
A
|
D
|
F
|
L
|
T
|
330 |
W
|
L
|
G
|
Y
|
V
|
N
|
S
|
L
|
I
|
N
|
340 |
H8 | |||||||||
P
|
L
|
L
|
Y
|
T
|
S
|
F
|
N
|
E
|
D
|
350 |
F
|
K
|
L
|
A
|
F
|
K
|
K
|
L
|
I
|
R
|
360 |
C-term | |||||
C
|
R
|
E
|
H
|
T
|
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine, tryptamine
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page